What is the meaning of clumping factor?

The clumping factor is a measurement of how density varies within a gaseous medium, and is commonly used in astrophysical settings where gas is not distributed uniformly.

What is the difference between coagulase and clumping factor?

Coagulase is an enzyme-like protein and causes plasma to clot by converting fibrinogen to fibrin. Staphylococcus aureus produces two forms of coagulase: bound and free. Bound coagulase (clumping factor) is bound to the bacterial cell wall and reacts directly with fibrinogen.

Which can be used to detect clumping factor?

The coagulase slide test is used to identify the presence of bound coagulase or clumping factor, which is attached to the cell walls of the bacteria. Bound coagulase reacts with the fibrinogen in plasma, causing the fibrinogen to precipitate.

What do Leukocidins do?

Leukocidins target phagocytes, natural killer cells, dendritic cells, and T lymphocytes and therefore targets both, innate and adaptive immune responses. Leukocidins fall into the category of bacterial invasin. Invasins are enzymatic secretions that help bacteria invade the host tissue to which they are attached.

Why is coagulase a virulence factor?

Coagulases are staphylococcal key virulence factors contributing to the development of pseudocapsules that promote abscess formation and infection persistence as well as staphylococcal bacteraemia and endocarditis.

What bacteria are coagulase positive?

Bacteria in the genus Staphylococcus are pathogens of man and other mammals. Traditionally they were divided into two groups on the basis of their ability to clot blood plasma (the coagulase reaction). The coagulase-positive staphylococci constitute the most pathogenic species S aureus.

How would you interpret a negative slide test and a positive tube test using the same organism?

How would you interpret a negative slide test and a positive tube test using the same organism? The slide test detects bound coagulase; the tube test detects both bound and free. A negative slide test indicates absence of bound coagulase, but positive tube indicates presence of free.

What is coagulase-positive staph?

Staphylococcus aureus and other coagulase-positive staphylococci (CoPS) are opportunistic pathogens associated with a large spectrum of diseases that range from skin and mucosal infections to life-threatening septicemias in humans and animals.

What is the importance of catalase and coagulase test in the identification of S. aureus?

The catalase test is a particularly important test used to determine whether the Gram + cocci is a staphylococci or a streptococci. Catalase is an enzyme that converts hydrogen peroxide to water and oxygen gas. The test is easy to perform; bacteria are simply mixed with H 2O 2.

What is the positive result in catalase test?

This test is used to identify organisms that produce the enzyme, catalase. This enzyme detoxifies hydrogen peroxide by breaking it down into water and oxygen gas. The bubbles resulting from production of oxygen gas clearly indicate a catalase positive result.