Can C. diff be treated with Flagyl?

Metronidazole (Flagyl) may be used in combination with vancomycin to treat serious C. difficile infection.

What IV fluid do you give for C. diff?

While metronidazole is widely used in the treatment of C difficile–associated diarrhea (CDAD), vancomycin was until recently the only antibiotic approved by the FDA for this indication.

What is better for C. diff Flagyl or vancomycin?

These drugs are equivalent for mild-to-moderate disease, but vancomycin is superior for severe disease. Both oral vancomycin and oral metronidazole are effective treatments for patients with Clostridium difficile infection (CDI).

Why is metronidazole not recommended for C. diff?

It is important to note that metronidazole is still recommended for the treatment of CDI in children according to the 2017 IDSA/SHEA guidelines. Keep in mind that prolonged or repeated courses of metronidazole increase the risk of neurotoxicity.

How fast does Flagyl work for C. diff?

Most patients respond in several days. In one study of patients with mild-to-moderate disease, symptoms resolved in an average of 3.0 days with vancomycin and 4.6 days with metronidazole.

HOW DO YOU GIVE metronidazole IV?

Metronidazole 500mg/100ml Intravenous Infusion should be infused intravenously at an approximate rate of 5 ml/minute (or one bag infused over 20 to 60 minutes). Oral medication should be substituted as soon as feasible.

Can metronidazole make C diff worse?

Even brief exposure to any single antibiotic can cause C difficile colitis. A prolonged antibiotic course or the use of 2 or more antibiotics increases the risk of disease. Moreover, antibiotics traditionally used to treat C difficile, vancomycin and metronidazole, have also been shown to cause disease.

Can vancomycin and Flagyl be taken together?

Interactions between your drugs No interactions were found between Flagyl and vancomycin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

How long does Flagyl take to work for C. diff?

Most patients respond in several days. In one study of patients with mild-to-moderate disease, symptoms resolved in an average of 3.0 days with vancomycin and 4.6 days with metronidazole. In the past, response rates to both drugs have been 95% or better.