When should a trough level be drawn?
When should a trough level be drawn?
A trough level is drawn immediately before the next dose of the drug is administered. A peak level is drawn 1 to several hours after the drug is administered (depending on the drug).
Why is vancomycin trough important?
Monitoring the level of vancomycin is important because its effectiveness relies on keeping blood levels above a minimum concentration for the entire duration of therapy (also referred to as total drug exposure).
What is the purpose of obtaining a trough level?
To adequately evaluate the appropriate dosage levels of many drugs, the collection and testing of specimens for trough and peak levels is necessary. The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug.
Why do you need peak and trough vancomycin?
Peak and trough serum concentrations are routinely measured to monitor vancomycin therapy. Optimal therapy depends upon maintaining a concentration above that necessary for antibacterial activity and is therefore determined by the trough concentration.
What is a normal vancomycin trough?
Trough concentrations are recommended for therapeutic monitoring of vancomycin, preferably acquired at steady-state (just before fourth dose). To avoid development of resistance, vancomycin trough levels should remain above 10.0 mcg/mL. Complicated infections require higher target levels, typically 15.0 to 20.0 mcg/mL.
How do you interpret a vancomycin trough?
How often do you do Vanco troughs?
Subsequent trough levels: o With dosage change: trough should be taken at new steady state* as described above. o Once target trough achieved: trough should be taken every 7-10 days in hemodynamically stable patients; may need more frequently if hemo-dynamically unstable, renal function changing, or patient is on …
What is the normal trough level for vancomycin?
Trough concentrations are recommended for therapeutic monitoring of vancomycin, preferably acquired at steady-state (just before fourth dose). To avoid development of resistance, vancomycin trough levels should remain above 10.0 mcg/mL. Complicated infections require higher target levels, typically 15.0 to 20.0 mcg/mL.
What time should a vancomycin trough be drawn?
DRUG. IV Peak: Infuse over 30 minutes,wait 30 minutes after infusion is complete to collect.
When should vancomycin trough be drawn?
vancomycin trough concentration should be drawn with morning labs pre-dialysis on Wednesday. If the level is 15-20 mcg/mL, then the patient should receive 750 mg of vancomycin after that dialysis, and with each subsequent dialysis session. The vancomycin levels would be drawn weekly.
Why do we check Vanco trough?
Trough serum vancomycin concentrations are the most accurate and practical method for monitoring efficacy. Traditionally vancomycin was believed to display time-dependent bacterial killing, in which case there is little evidence for the use of target peak concentrations. Similarly, this is not recommended in the TG or the AMH.
