What is the mechanism of action for antifungal drugs?

The two main mechanisms of action of antifungals targeting the cell wall are related to the inhibition of chitin and β-glucan synthesis. In the period between 2001 and 2006, the echinocandin class of drugs, represented by caspofungin, micafungin, and anidulafungin, was developed.

What are the mechanisms of antifungal drug resistance?

Many different types of mechanisms contribute to the development of resistance to antifungals. These mechanisms include alteration in drug target, alteration in sterol biosynthesis, reduction in the intercellular concentration of target enzyme, and overexpression of the antifungal drug target.

What is the mechanism of action of fluconazole?

Mechanism of Action Fluconazole interacts with 14-demethylase, a cytochrome P-450 enzyme responsible for catalyzing the conversion of lanosterol to ergosterol. [3] As ergosterol forms a critical part of the fungal cell membrane, fluconazole inhibits the synthesis of ergosterol to increase cellular permeability.

What is the mechanism of action of the antifungal drug griseofulvin?

Mechanism: In addition to its direct vasodilatory effect, griseofulvin has a fungistatic effect by its ability to disrupt the mitotic spindle structure of the fungal cell which arrests metaphase in cell division. It deposits in the skin, hair, nails, fat and skeletal muscles.

What is the mechanism of action of azole antifungals?

Mechanism of Action of Azoles Azoles exert their action by inhibiting the C14α demethylation of lanosterol in fungi, which interferes with the synthesis of ergosterol in the fungal cell membrane.

What is the mechanism of action of griseofulvin?

Griseofulvin is fungistatic, however the exact mechanism by which it inhibits the growth of dermatophytes is not clear. It is thought to inhibit fungal cell mitosis and nuclear acid synthesis. It also binds to and interferes with the function of spindle and cytoplasmic microtubules by binding to alpha and beta tubulin.