What is the basic underlying pathophysiology of type 2 diabetes?

Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders worldwide and its development is primarily caused by a combination of two main factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond to insulin [1].

What is the pathophysiologic difference between Type 1 and type 2 diabetes?

The main difference between the type 1 and type 2 diabetes is that type 1 diabetes is a genetic condition that often shows up early in life, and type 2 is mainly lifestyle-related and develops over time. With type 1 diabetes, your immune system is attacking and destroying the insulin-producing cells in your pancreas.

What is the pathophysiology associated with diabetes?

The pathophysiology of diabetes involves plasm concentrations of glucose signaling the central nervous system to mobilize energy reserves. It is based on cerebral blood flow and tissue integrity, arterial plasma glucose, the speed that plasma glucose concentrations fall, and other available metabolic fuels.

What are the 3 P’s symptoms associated with T2DM?

The three P’s of diabetes are polydipsia, polyuria, and polyphagia. These terms correspond to increases in thirst, urination, and appetite, respectively. The three P’s often — but not always — occur together.

What is the anatomy and physiology of type 2 diabetes?

When you have type 2 diabetes, your fat, liver, and muscle cells do not respond correctly to insulin. This is called insulin resistance. As a result, blood sugar does not get into these cells to be stored for energy. When sugar cannot enter cells, a high level of sugar builds up in the blood.

What is the pathogenesis of hyperglycemia in type 2 diabetes?

Abstract. The most important causes of hyperglycaemia in the course of diabetes mellitus type 2 are discussed. Those include: insulin secretion disorders, resistance to the insulin and overproduction of glucose in the liver.

What is the basic pathophysiology of type 1 diabetes?

Type 1 DM is the culmination of lymphocytic infiltration and destruction of insulin-secreting beta cells of the islets of Langerhans in the pancreas. As beta-cell mass declines, insulin secretion decreases until the available insulin no longer is adequate to maintain normal blood glucose levels.

What happens in type 2 diabetes mellitus?

What are the 3 cardinal signs of diabetes?

The main symptoms of diabetes are described as the three polys – polyuria, polydipsia, and polyphagia. Individuals with high risk for developing diabetes should be alert to these symptoms and seek medical attention if they notice the above symptoms.

What body system does type 2 diabetes affect?

The long-term effects of diabetes include damage to large and small blood vessels, which can lead to heart attack and stroke, and problems with the kidneys, eyes, feet and nerves. The good news is that the risk of long-term effects of diabetes can be reduced.

How does type 2 diabetes affect glucose metabolism?

Abstract. Glucose production is inappropriately increased in people with type 2 diabetes both before and after food ingestion. Excessive postprandial glucose production occurs in the presence of decreased and delayed insulin secretion and lack of suppression of glucagon release.

How does type 2 diabetes work?

When you have type 2 diabetes, your body still breaks down carbohydrate from your food and drink and turns it into glucose. The pancreas then responds to this by releasing insulin. But because this insulin can’t work properly, your blood sugar levels keep rising. This means more insulin is released.

What is the difference between type 2 diabetes and type 2 diabetes mellitus?

Type 2 diabetes is a chronic disease. It is characterized by high levels of sugar in the blood. Type 2 diabetes is also called type 2 diabetes mellitus and adult-onset diabetes. That’s because it used to start almost always in middle- and late-adulthood.

What happens to insulin receptors in type 2 diabetes?

In type 2 diabetes, we believe that insulin binds to the receptor normally, but the signal is not sent into the cell, the cells do not take up glucose and the resulting high blood glucose levels cause organ damage over time.

What is dawn phenomenon and Somogyi effect?

Overview. The dawn phenomenon and the Somogyi effect cause high blood sugar levels, especially in the morning before breakfast, in people who have diabetes.

What are the 3 P’s in diabetic ketoacidosis?

The three Ps of DKA: Polydipsia—thirst. Polyuria—urination. Polyphagia—appetite.

What causes diabetes type 2?

Although not everyone with type 2 diabetes is overweight, obesity and an inactive lifestyle are two of the most common causes of type 2 diabetes. These things are responsible for about 90% to 95% of diabetes cases in the United States.