How do you get KSHV?

KSHV is transmitted mainly through saliva. It can also be spread through sexual contact, blood transfusion, or transplants. After it enters the body, the virus can infect different kinds of cells, especially cells that line blood vessels and lymphatic vessels.

What cells does KSHV infect?

Kaposi’s sarcoma associated herpesvirus (KSHV or HHV-8) infects a variety of in vivo target cells such as endothelial cells, B cells, monocytes, epithelial cells, and keratinocytes.

Does HHV 8 causes Kaposi’s sarcoma?

Kaposi’s sarcoma is caused by a virus called the human herpesvirus 8 (HHV-8), also known as the Kaposi’s sarcoma-associated herpesvirus (KSHV). The virus is thought to be spread during sex, through blood or saliva, or from a mother to her baby during birth.

What is Lana virus?

The latency-associated nuclear antigen (LANA-1) or latent nuclear antigen (LNA, LNA-1) is a Kaposi’s sarcoma-associated herpesvirus (KSHV) latent protein initially found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS.

How common is KSHV?

In the United States, studies have found that less than 10% of people are infected with KSHV. The infection is more common in people infected with HIV than in the general population in the United States. KSHV infection is also more common in men who have sex with men than in men who only have sex with women.

Where is KSHV located?

KSHV is present in the vast majority of KS tumour cells (that is, spindle cells), expressing the latent viral proteins, including viral cyclin, viral FLICE inhibitory protein, latency-associated nuclear antigen (LANA) and a group of viral microRNAs.

What type of virus is KSHV?

Kaposi sarcoma (KS) is caused by infection with a virus called the Kaposi sarcoma–associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). KSHV is in the same family as Epstein-Barr virus (EBV), the virus that causes infectious mononucleosis (mono) and is linked to several types of cancer.

What are the symptoms of HHV-8?

Clinical Manifestations Primary infection with HHV-8 in young, immunocompetent children may be asymptomatic or may present as a self-limited mononucleosis-like illness consisting of fever, mild upper respiratory symptoms, and a maculopapular rash.

What is Lana protein?

Latency-associated nuclear antigen (LANA) encoded by open reading frame 73 (ORF73) is the major latent protein expressed in all forms of KSHV-associated malignancies. LANA is a large (222–234 kDa) nuclear protein that interacts with various cellular as well as viral proteins.

What does KSHV cause?

How many people have KSHV?

In the United States, studies have found that less than 10% of people are infected with KSHV.