Does fosphenytoin cause hypotension?
Does fosphenytoin cause hypotension?
Fosphenytoin is much more expensive than phenytoin but has a lower risk of local tissue complications (229). Adverse effects include pruritus and perineal paresthesias at high rates of administration. Cardiac arrhythmias and hypotension can occur.
What are the side effects of fosphenytoin?
Fosphenytoin injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- itching, burning, or tingling sensation.
- uncontrollable eye movements.
- abnormal body movements.
- loss of coordination.
- confusion.
- dizziness.
- weakness.
- agitation.
What are the adverse effects of infusing fosphenytoin too rapidly?
The following serious adverse reactions are described elsewhere in the labeling: Cardiovascular Risk Associated with Rapid Infusion [see WARNINGS AND PRECAUTIONS]…Common side effects may include:
- dizziness, drowsiness;
- unusual or involuntary eye movements;
- vomiting;
- itching; or.
- problems with balance or muscle movement.
Does phenytoin drop blood pressure?
In previous decades, several patients experienced adverse effects of intravenous phenytoin such as severe heart arrhythmias and decrease of blood pressure.
Why does phenytoin cause hypotension?
[2] It is a Class IB antiarrhythmic agent which inhibits phase 0 inward intracellular sodium currents, resulting in widening of the QRS complex in the extranodal cardiac tissue as well as slowing of conduction.
Does IV Keppra cause hypotension?
Discussion: Levetiracetam in large ingestions appears to cause bradycardia and hypotension that is potentially responsive to atropine and intravenous fluids.
Why is fosphenytoin preferred over phenytoin?
Fosphenytoin is a parenterally administered prodrug of phenytoin, used in the treatment of patients with seizures. Advantages of fosphenytoin over phenytoin include more rapid intravenous administration, no need for an intravenous filter, and a lower potential for local tissue and cardiac toxicity.
Is fosphenytoin and phenytoin same?
Fosphenytoin, a phenytoin prodrug, has the same pharmacological properties as phenytoin but none of the injection site and cardiac rhythm complications of intravenous infusions of phenytoin.
What causes purple glove syndrome?
Cause. Purple glove syndrome is caused by the intravenous anticonvulsant phenytoin. This medication has many already established neurological side effects, however glove syndrome is a rare, but very serious adverse effect that may lead to limb amputations.
What is the most common side effects of phenytoin?
Common side effects
- Headaches. Make sure you rest and drink plenty of fluids.
- Feeling drowsy, sleepy or dizzy. As your body gets used to phenytoin, these side effects should wear off.
- Feeling nervous, unsteady or shaky.
- Feeling or being sick (nausea or vomiting)
- Constipation.
- Sore or swollen gums.
Is phenytoin contraindicated in hypotension?
[3] It is contraindicated in sinus bradycardia, sinoatrial block, second- and third-degree atrioventricular block, and Adams–Stokes syndrome, where adverse cardiovascular reactions including severe hypotension and cardiac arrhythmias can develop.
Print Share. Commonly reported side effects of fosphenytoin include: pruritus, ataxia, dizziness, drowsiness, nystagmus, burning sensation at injection site, and pain at injection site.
What is the loading dose of fosphenytoin sodium?
The non-emergent loading dose of Fosphenytoin Sodium Injection is 10 to 20 mg PE/kg given IV or IM. Following either the loading dose for Status Epilepticus or a Non-emergent situation, the initial daily maintenance dose of Fosphenytoin Sodium Injection is 4 to 6 mg PE/kg/day in divided doses at a rate no greater than 150 mg PE/min.
What are the medication errors associated with fosphenytoin sodium injection?
Medication errors associated with Fosphenytoin Sodium Injection have resulted in patients receiving the wrong dose of Fosphenytoin. Fosphenytoin Sodium Injection is marketed in 2 mL vials containing a total of 100 mg PE and 10 mL vials containing a total of 500 mg PE. The concentration of each vial is 50 mg PE/mL.
What are the signs and symptoms of phenytoin toxicity?
Initial symptoms of acute phenytoin toxicity are nystagmus, ataxia, and dysarthria. Other signs include tremor, hyperreflexia, lethargy, slurred speech, nausea, vomiting, coma, and hypotension. Death is caused by respiratory and circulatory depression. The lethal dose of phenytoin in adults is estimated to be 2 to 5 grams.
