Is KSHV a retrovirus?

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development. Oncogene. 2018 Aug;37(33):4534-4545.

Is KSHV an RNA virus?

PAN’s Labyrinth: molecular biology of Kaposi’s sarcoma-associated herpesvirus (KSHV) PAN RNA, a multifunctional long noncoding RNA. Viruses. 2014;6:4212–26.

How is KSHV transmitted?

KS is the result of infection with a gamma herpesvirus known as Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8). It is in the same family as the Epstein-Barr virus, which causes mononucleosis. KSHV is transmitted mainly through saliva.

How can you get HHV-8?

HHV-8 is transmitted through saliva, but infection may also be acquired through sexual intercourse, blood transfusion, and organ transplantation [141]. HHV-8 causes Kaposi sarcoma (KS) and is linked with primary effusion lymphoma and multicentric Castleman disease (Table 8.4) [142].

How do you know if you have HHV-8?

Most people who contract HHV-8 do not show symptoms, 19 but some young children and immunocompetent adults may develop symptoms such as: Fever. Rash. Swollen lymph glands.

What causes Kaposi sarcoma?

Kaposi’s sarcoma is caused by a virus called the human herpesvirus 8 (HHV-8), also known as the Kaposi’s sarcoma-associated herpesvirus (KSHV). The virus is thought to be spread during sex, through blood or saliva, or from a mother to her baby during birth.

Is Kaposi’s sarcoma a DNA or RNA virus?

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the most recently discovered human tumor virus, responsible for Kaposi’s sarcoma, primary effusion lymphoma, some forms of Castleman’s disease, and several non-neoplastic syndromes. It is a large, double-stranded DNA virus infecting primarily endothelial and B cells.

What does kshv/hhv8 stand for?

Kaposi’s sarcoma herpesvirus/ Human herpesvirus-8 (KSHV/HHV8), and the oncogenesis of Kaposi’s sarcoma Enrique A. Mesri, Ethel Cesarman, and Chris Boshoff Enrique A. Mesri

Is there a cure for kshv/hhv8?

Even after so many years of discovery of KSHV/HHV8, there is no known cure for KSHV associated tumorigenesis. In 1872, Moritz Kaposi described a blood vessel tumor (originally called “idiopathic multiple pigmented sarcoma of the skin”) that has since been eponymously named Kaposi’s sarcoma (KS).

What is the mode of transmission of HHV-8?

HHV-8 Transmission/Preventing Exposure The mode (s) of transmission of HHV-8 remains unclear, but epidemiologic and virologic data suggest that saliva is a source of infectious virus and may be an important route of transmission.

What is HHV8 associated Kaposi sarcoma (KS)?

HHV8 associated Kaposi sarcoma (endothelial and spindle cells, 92% sensitive and highly specific), primary effusion lymphoma, multicentric Castleman disease