Does malaria cause Hepatosplenomegaly?

Abstract. In sub-Saharan Africa, chronic hepatosplenomegaly, with palpable firm/hard organ consistency, is common, particularly among school-aged children. This morbidity can be caused by long-term exposure to malaria, or by Schistosoma mansoni, and it is exacerbated when these two occur together.

Which malaria species causes splenomegaly?

In P falciparum infection heavy parasitemia is more common, so increased clearance of parasitized and non-parasitized erythrocytes occurs in the presence of splenomegaly [5]. White MS et al in 1986 have reported splenomegaly in 53% cases of acute attack of uncomplicated malaria [6].

What happens splenomegaly?

An enlarged spleen typically causes no signs or symptoms, but sometimes it causes: Pain or fullness in the left upper belly that can spread to the left shoulder. A feeling of fullness without eating or after eating a small amount because the spleen is pressing on your stomach. Low red blood cells (anemia)

What is the treatment for hepatosplenomegaly?

When the underlying cause is cancer, you need suitable treatments that may include chemotherapy, radiotherapy, and surgery to remove the tumor. Liver transplant. If your case is severe, such as being in the final stages of cirrhosis, you may require a liver transplant.

Which type of malaria causes splenomegaly?

Background. The hyper-reactive malarial splenomegaly syndrome (HMS) is a leading cause of massive splenomegaly in malaria-endemic countries. HMS is caused by a chronic antigenic stimulation derived from the malaria parasite.

What is Schizont in malaria?

schizont. / (ˈskɪtsɒnt) / noun. a cell formed from a trophozoite during the asexual stage of the life cycle of sporozoan protozoans, such as the malaria parasite.

What is recrudescence in malaria?

“Recrudescence” is the term for recurrence of infection with all malaria species including P. falciparum, P. malariae and P. knowlesi, which lack hypnozoites. This occurs when the infection (unless a new infection) has persisted in the blood at undetectable levels and then becomes detectable again.

How is Tropical splenomegaly treated?

The treatment of tropical splenomegaly syndrome involve administration of antimalarial drug followed by prophylaxis for prolonged periods of time. This remove the add-on antigenic stimulus of repeated malarial infections and allow the reticuloendothelial system to return to normal.