Are Promonocytes blasts?

The promonocyte is considered a “blast equivalent.” Monoblasts have round nuclei with delicate lacy chromatin and one or more prominent nucleoli (Figure 1a).

What are immature monocytes?

LP31551-2 Monocytes.immature. A monocyte is a mononuclear leukocyte, intimately involved in the initiaton of an immune response. It also protects against blood-borne pathogens and migrates quickly to sites of infection in the tissues. Monocytes are usually identified in stained smears by their large bilobed nucleus.

Are Monoblasts MPO positive?

Cytochemistry: Monoblasts are typically MPO negative and promonocytes are MPO variable. Both monoblasts and promonocytes stain positive for non-specific esterase (NSE), however NSE may often be negative.

What do Monoblasts do?

Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which, in turn, develop into macrophages. They then are seen as macrophages in the normal peripheral blood and many different tissues of the body.

What is a Promyelocyte?

A promyelocyte is a type of myeloid cell that normally matures to granulocytes. Eosinophils, neutrophils, and basophils are the three types of mature granulocytes. Leukemia is defined as the uncontrolled proliferation of abnormal leukocytes in the blood and bone marrow.

How do you identify a blast cell?

In general, blasts are cells that have a large nucleus, immature chromatin, a prominent nucleolus, scant cytoplasm and few or no cytoplasmic granules. Blasts may not have all of these features. Cell size – blasts are often medium to large cells.

What are immature lymphocytes?

Immature lymphocytes include lymphoblasts and prolymphocytes. Lymphoblasts, the morphologically most immature cells of the lymphocytic series, are 10 to 20 u in diameter and usually round or oval, originating in the lymphoid tissue and marrow.

What are the causes of Monocytosis?

It’s often linked to infectious diseases like mononucleosis or an autoimmune disease like lupus. Some medications can cause monocytosis. It’s also linked to conditions such as blood disorders and certain cancers. But you can develop a high monocyte count for reasons that are less serious.

What CD markers are monoblasts?

Monoblasts usually express MPO, HLA-DR, CD4, CD11b, CD11c, CD33, and CD65. The cells of some monocytic leukemias express CD117, but CD34 is rarely detected.

What is the difference between myelocyte and promyelocyte?

Promyelocyte is the second stage of myeloblast development, and it is the largest cell type of the myeloid lineage. Myelocyte is the third stage of myeloblast development which can be differentiated into eosinophils, basophils, and neutrophils. Promyelocyte cell size ranges from 12 to 25 µm.