Does modafinil help sleep apnea?

The wake-promoting agent modafinil is approved for the treatment of excessive sleepiness associated with obstructive sleep apnea (OSA), shift work disorder (SWD), and narcolepsy. In OSA, modafinil is recommended for use as an adjunct to standard therapies that treat the underlying airway obstruction.

Can Provigil help with sleep apnea?

Provigil (modafinil) is a prescription medication. It’s most often used to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, and shift work. Provigil belongs to a class of medications called stimulants.

Is modafinil FDA approved for sleep apnea?

It is used in the treatment of conditions which cause excessive daytime sleepiness. In the United States, modafinil is FDA-approved for the treatment of the following in adults: narcolepsy, sleep work shift disorder, and obstructive sleep apnea (adjunct to continuous positive airway pressure (CPAP)).

What medications should you avoid for obstructive sleep apnea?

Many medications can make sleep apnea worse, including:

  • Barbiturates.
  • Benzodiazepines.
  • Some beta-blockers.
  • Opioids.
  • Sildenafil (an erectile dysfunction drug)
  • Testosterone.
  • Drugs that cause you to gain weight.

Does modafinil improve sleep quality?

We found that modafinil 400mg given in a single, early morning dose leads to improvements in sleep and decreases in objective and subjective measures of daytime sleepiness.

Does modafinil improve sleep?

Modafinil improved wakefulness by 50% to 75%, as measured by three standardized, validated sleepiness tests: the Multiple Sleep-Latency Test (MSLT), which objectively measures the time required to fall asleep; the Maintenance of Wakefulness Test (MWT), which objectively measures ability to remain awake; and the Epworth …

Does modafinil have a black box warning?

Modafinil (Provigil) and armodafinil (Nuvigil) have a new bolded warning due to reports of serious rash, including Stevens-Johnson syndrome, which can lead to hospitalization for infection.

Does melatonin worsen sleep apnea?

Obstructive Sleep Apnea is caused following the relaxation of throat muscles, which obstruct airway flow while a sufferer is asleep. Too much melatonin will actually increase this relaxation and potentially put a patient at risk.

What aggravates sleep apnea?

Congestive heart failure, high blood pressure, type 2 diabetes and Parkinson’s disease are some of the conditions that may increase the risk of obstructive sleep apnea. Polycystic ovary syndrome, hormonal disorders, prior stroke and chronic lung diseases such as asthma also can increase risk.

How long can you stay awake with modafinil?

In trials on healthy people, modafinil allowed users to stay up for almost two days while remaining nearly as focused, alert and capable of problem-solving as the well-rested. After eight hours of sleep, Garreau writes, users can rise and go another 40 hours.

Does modafinil affect deep sleep?

The strongest effect of modafinil on sleep architecture appears to be the increase stage N3 (slow-wave) sleep time. Slow-wave sleep was significantly higher in the modafinil group and more than double that in placebo at all time points. From a clinical perspective, this effect may also be particularly relevant.