How are sublingual tablets formulation?
How are sublingual tablets formulation?
Sublingual tablets were prepared using ispaghula husk powder, gellan gum, sodium alginate as super disintegrating polymers and citric acid, tartaric acid and camphor as permeation enhancers by direct compressible technique and evaluated for weight variation, thickness, friability, content uniformity, hardness.
What is an example of sublingual tablet?
Examples of commonly prescribed sublingual tablets include nitroglycerin, loratadine, mirtazapine, and rizatriptan (Table 1-2). Some diseases alter rates of drug absorption.
What is sublingual tablets used for?
Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.
What is correct for sublingual route?
Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.
How effective is sublingual medication?
1) Sublingual medications Administration through direct absorption into the mouth provides an advantage to medications you swallow. Sublingual drugs go into effect more quickly because they don’t have to go through your stomach and digestive system before being absorbed into the bloodstream.
How effective is sublingual absorption?
The absorption of the drug through the sublingual route is 3 to 10 times greater than oral route and is only surpassed by hypodermic injection. For these formulations, the small volume of saliva is usually sufficient to result in tablet disintegration in the oral cavity.
Why is sublingual more effective?
One reason for selecting the sublingual route is to avoid drug destruction. Because gastric acid and intestinal and hepatic enzymes are bypassed, sublingual absorption can be more efficient overall for certain drugs than intestinal uptake. The onset of drug effect may also be quicker than with oral ingestion.
What are the types of tablet?
The various tablet types are described as follows:
- a. Compressed tablets.
- b. Sugar-coated Tablets.
- c. Film-Coated Tablets.
- d. Effervescent Tablets.
- e. Enteric-coated Tablets.
- f. Chewable Tablets.
- g. Buccal and Sublingual Tablets.
What affects sublingual absorption?
The use of the base or the salt and the vehicle employed had a more important effect on sublingual absorption than on oral absorption. Aconitine in alcohol was more rapidly absorbed sublingually than aconitine hydrochloride in water although there was no difference in subcutaneous absorption.
Where do you place a sublingual tablet?
If you are using the sublingual tablet:
- Do not cut, crush, chew, or swallow it.
- Place the tablet under the tongue until it is dissolved.
- If you take 2 or more tablets at a time, place all of the tablets in different places under the tongue at the same time.
Which of the following is an advantage of sublingual administration?
An advantage of sublingual drug administration is that the drug enters directly into the systemic circulation, bypassing the enterohepatic circulation.
Is sublingual better?
