How do you dissolve a poloxamer?

Poloxamer 407 aqueous solutions can be prepared by two methods; in both, the solubilization of the polymer in the aqueous phase is the starting point, but in the “cold” procedure, the dissolution is performed at 4 °C until a clear solution is formed, while in the “hot” method, the aqueous phase is heated to 70–90 °C.

Is poloxamer soluble in water?

All poloxamers are freely soluble in water and in alcohol. Poloxamer 124 is freely soluble in isopro- pyl alcohol and in propylene glycol; poloxamer 237 is sparingly soluble in isopropyl alcohol and in xylene; poloxamer 338 is sparingly soluble in propylene glycol; poloxamer 124 is freely soluble in xylene.

Is poloxamer 188 the same as Pluronic f68?

Poloxamer 188 It is a non-ionic detergent with an average molecular weight of 8400Da consisting of a central polyoxypropylene flanked by two polyoxyethylene molecules. Poloxamer 188 is equivalent to Pluronic® F-68.

What is poloxamer 188 BASF?

Currently, excipient-grade poloxamer 188 NF, marketed by BASF under the Kolliphor® P188 brand, is a polymer used in a variety of pharmaceutical and biological applications, such as a shear protectant in cell culture production. Poloxamer 188 is the starting material for Mast’s lead product candidate.

What is the difference between poloxamer 188 and 407?

Given its low toxicity, PXM-188 is one of the most common surfactants in parenteral applications [3], [5]. PXM-407 is also an ABA block type copolymer, containing approximately 70% PEO and 30% PPO. PXM-407 exhibits reverse thermal gelation in concentrations above 20%, and has a non-toxic nature [6], [7].

Is poloxamer 188 a surfactant?

Poloxamer P188 is a nonionic copolymer surfactant with a triblock structure, comprised of two hydrophilic segments, the poly(oxyethylene) (PEO), and a central hydrophobic segment, the poly(oxypropylene) (PPO), taken together by ether bonds.

Is poloxamer 188 toxic?

Poloxamer 188 (P188) is a nonionic block copolymer chemical surfactant known to have cytoprotective, rheologic, anti-inflammatory, and anti-thrombotic activity combined with minimal toxicity.

What is poloxamer used for?

What is it? Poloxamers are polymers used for drug delivery as formulation excipients. They are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. They are also used in topical dosage forms and rectal suppositories.

How do you dissolve Pluronic F127 in water?

Dissolve 1 g of Pluronic® F-127 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Pluronic® F-127 in 10 mL of anhydrous dimethyl sulfoxide (DMSO) to make a 20% (w/v) stock solution. These may require heating from 40 to 50 °C for about 30 minutes. Store solution at room temperature.

How do you dissolve a F127?

Dissolve 2 g of Pluronic F-127 in 10 mL of anhydrous dimethylsulfoxide (DMSO) to give a 20% (w/v) stock solution. This may require heating at ~40° for about 20 minutes. Store both solid and solution at room temperature. Do not refrigerate or freeze the solutions because Pluronic F-127 may come out of solution.