How does Alizin work for pyometra?

Alizine® (aglepristone) is a commercially available progesterone receptor antagonist. Aglepristone has minimal or no side effects and has been used very effectively to treat closed pyometras as it causes cervical opening with no or minimal uterine contractions.

How quickly does Alizin work?

It does not affect future gestations or fertility. Fast, simple termination of pregnancy. From 0-45 days after mating. Abortion is achieved, on average, 3–4 days after treatment but it may take up to 10 days.

When should Alizin be given?

therefore, the optimal time for diagnosis and treatment of a misalliance with Alizin® is prior to 35 days of gestation* (though Alizin® is registered for use up to Day 45 after mating).

What is the best antibiotic for pyometra in dogs?

In conclusion, aglepristone alone can be effective and safe for the treatment of metritis and to induce cervical opening in closed pyometra. The association of aglepristone and cloprostenol was effective in the medical treatment for open and closed pyometra.

What are the side effects of Alizin in dogs?

Oedema, skin thickening, local lymph-node enlargement and ulceration may occur. All local reactions are reversible and will usually disappear within 28 days after injection. In field trials, administration of the veterinary medicinal product induced haematological/biochemical changes in 4.5 % of dogs.

Can Pyometra come back after surgery?

Pyometra can recur. The disease is resolved more slowly (over a week or so). There is a possibility of uterine rupture with the contractions. This would cause peritonitis and escalates the life-threatening nature of the disease.

What can you give a dog to abort puppies?

Mifepristone (RU486): This well-known drug acts as a progesterone antagonist. Small clinical trials have demonstrated that his drug is very effective in terminating canine pregnancy after 25-30 days of gestation, and without apparent adverse effects.

How do you dispose of Alizin?

Alizin is an oil-based product that may cause prolonged local reactions at the site of injection. Disposal Method: Dispose of this product only by using according to the label, or at an approved landfill, or other approved facility.

Can dogs get pyometra twice?

Dogs and cats are susceptible to developing pyometra again after medical treatment and should have an ovariohysterectomy performed when their breeding purposes are finished.