How fast can you infuse REMICADE?

REMICADE® is administered by intravenous (IV) infusion over a period of not less than 2 hours.

What is the infusion rate for REMICADE?

Rapid REMICADE infusions were administered at a rate of 100 mL/h for 15 minutes followed by a rate of 300 mL/h over 1 hour. Patients were eligible for rapid infusions if they received at least 6 infusions at the standard rate (2 hours including 3 induction doses and 3 maintenance doses).

Can REMICADE be given over 1 hour?

Conclusions: During maintenance therapy, infliximab infusion can be safely administered over 1h in patients with no past history of significant infliximab infusion reaction. Corticosteroid premedication had no impact on the infusion reaction rates.

How long does it take to infuse infliximab?

Infliximab is usually given through a drip into a vein. This is called an intravenous infusion. It’s usually done in a hospital and takes about two hours.

How many mg are in a vial of REMICADE?

Each REMICADE vial contains 100 mg of the infliximab antibody. Reconstitute each REMICADE vial with 10 mL of Sterile Water for Injection, USP, using a syringe equipped with a 21-gauge or smaller needle as follows: Remove the flip-top from the vial and wipe the top with an alcohol swab.

How long is REMICADE stable once mixed?

A study conducted to evaluate the stability of REMICADE after reconstitution with Sterile Water for Injection (SWFI), 5% Dextrose (D5W), and 0.9% Sodium Chloride (NS) and stored at ambient room temperature suggests that REMICADE reconstituted with SWFI or NS remains stable for 24 hours at room temperature.

How do you dilute REMICADE?

Dilute the total volume of the reconstituted REMICADE solution dose to 250 mL with 0.9% Sodium Chloride Injection, USP, by withdrawing a volume of 0.9% Sodium Chloride Injection, USP, equal to the volume of reconstituted REMICADE from the 0.9% Sodium Chloride Injection, USP, 250 mL bottle or bag.

Why is Tylenol given with REMICADE?

To help prevent infusion reactions, you may be given drugs such as Tylenol (acetaminophen) or a corticosteroid. Remicade infusions usually last about 2 hours. Infusions are given at the same rate regardless of the condition you’re taking the drug to treat.

Is REMICADE a black box drug?

The makers of Remicade, a biological treatment for various inflammatory disorders involving the immune system, have updated information on the medication to include a Boxed Warning of an invasive fungal infection and a rare type of T-cell Lymphoma.

How long is REMICADE stable at room temperature?

Store unopened REMICADE vials in a refrigerator at 2°C to 8°C (36°F to 46°F). If needed, unopened REMICADE vials may be stored at room temperatures up to a maximum of 30ºC (86°F) for a single period of up to 6 months but not exceeding the original expiration date.

How do you reconstitute REMICADE?

The REMICADE infusion should begin within 3 hours of preparation.

  1. Calculate the dose and the number of REMICADE vials needed.
  2. Reconstitute each REMICADE vial with 10 mL of Sterile Water for Injection, USP, using a syringe equipped with a 21-gauge or smaller needle.