Is G-CSF the same as GM-CSF?

In summary, although G-CSF and GM-CSF are molecularly cloned myeloid growth factors, their biology and clinical effects differ. GM-CSF has a much wider activity spectrum in animals and humans. In persons with lung infection and/or ARDS, GM-CSF may be a safer drug than G-CSF.

What does GM-CSF stands for?

granulocyte-macrophage colony-stimulating factor
A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent. Also called granulocyte-macrophage colony-stimulating factor and sargramostim.

What is GM-CSF protein?

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine that promotes myeloid cell development and maturation, and dendritic cell differentiation and survival in vitro.

What is the difference between filgrastim and pegfilgrastim?

Treatment regimens differ slightly: filgrastim is administered daily for up to a maximum of 14 days, either subcutaneously or intravenously, whereas pegfilgrastim treatment involves a single SC dose per chemotherapy cycle with no restrictions to every 14-day cycles only.

What is GM blood test?

Impaired signaling by granulocyte/macrophage-colony stimulating factor (GM-CSF) drives the pathogenesis of two diseases (autoimmune and hereditary pulmonary alveolar proteinosis (PAP)) representing over ninety percent of patients who develop PAP syndrome but not a broad spectrum of diseases that cause PAP by other …

Who secretes GM-CSF?

GM-CSF is produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts (2).

Does G-CSF increase WBC?

G-CSF (granulocyte-colony stimulating factor) is a type of protein called a growth factor. It increases the number of some types of white blood cells in the blood. It can be used with chemotherapy. It can also be used before and after a stem cell transplant.

Why is pegfilgrastim given 24 hours after chemo?

This medication is usually given at least 24 hours after chemotherapy to stimulate the growth of new, healthy, white blood cells (WBC).