Is valproate Semisodium the same as valproic acid?

Sodium valproate and semisodium valproate are similar to valproic acid and work in the same way. However, these medicines are used to treat different conditions and doses will vary.

What’s the difference between sodium valproate and Semisodium valproate?

Semisodium valproate comprises equimolar amounts of sodium valproate and valproic acid (1, 2). It is also known as divalproex sodium (USAN). However, only certain strength of formulation is available in the market (See BNF for details) unless liquid formulation is being used.

How do you administer IV sodium valproate?

Sodium valproate injection may be given by direct slow intravenous injection or by infusion using a separate intravenous line in normal saline, dextrose 5%, or dextrose saline. Dosage requirements vary according to age and body weight. Each vial of sodium valproate injection is for single dose injection only.

What is valproate semisodium used for?

Valproate semisodium is prescribed as a mood stabiliser in bipolar disorder. It is a mixture of two similar ingredients – valproic acid and sodium valproate. It will have been given to you to help keep your mood within normal limits by helping to control the episodes of mania.

What is valproate Semisodium used for?

Is sodium valproate the same as Epilim?

Epilim belongs to a group of medicines called anticonvulsants. These medicines are thought to work by controlling brain chemicals which send signals to nerves so that seizures do not happen. Epilim 100 mg Crushable tablets contain 100 mg of the active ingredient sodium valproate.

Can valproic acid be given IV push?

Conclusions: Rapid administration of undiluted valproate is safe and well tolerated at infusion rate up to 10 mg/kg/min and doses of up to 30 mg/kg. The lack of serious cardiovascular, neurological, hepatic, or local adverse effects supports the use of VPA in emergent situations.

How do you give epilim IV?

Epilim IV may be given by direct slow intravenous injection or by slow intravenous infusion in 0.9% NaCL (normal saline), 5% glucose solution or glucose saline, using a separate intravenous line. The recommended concentration of the intravenous infusion solution is 4 mg/mL, with 8 mg/mL being the maximum concentration.