What are examples of anticholinesterase?


  • Reminyl (galantamine)
  • Aricept (donepezil)
  • Neostigmine (neostigmine)
  • Mestinon (pyridostigmine)
  • Elexon (rivastigmine)

What are anticholinesterase inhibitors used for?

The main use of cholinesterase inhibitors is for the treatment of dementia in patients with Alzheimer’s disease. People with Alzheimer’s disease have reduced levels of acetylcholine in the brain. Cholinesterase inhibitors have been shown to have a modest effect on dementia symptoms such as cognition.

What is the difference between anticholinergic and anticholinesterase?

What is the difference between anticholinergics and cholinesterase inhibitors? Cholinesterase inhibitors increase the amount of acetylcholine and its effects. Anticholinergics block acetylcholine and stop it from working! It is not advisable to use anticholinergics in a patient who is on cholinesterase inhibitors.

What class of drug is anticholinesterase?

The reversible anticholinesterases may be classified as simple quaternary ammonium compounds (edrophonium) or carbamate ester derivatives, including tertiary amines (physostigmine), and quaternary amines (neostigmine and ambenonium).

How do Anticholinesterase drugs work?

Anticholinesterases are drugs that prolong the existence of acetylcholine after it is released from cholinergic nerve endings by inhibiting both acetylcholinesterase and butyrylcholinesterase.

Is atropine an anticholinesterase?

Atropine is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having anticholinesterase activity as well as organophosphorus or carbamate insecticides in adults and pediatric patients weighing more than 41 kg (90 pounds).

What happens if acetylcholinesterase is inhibited?

The inhibition of the enzyme leads to accumulation of ACh in the synaptic cleft resulting in over-stimulation of nicotinic and muscarinic ACh receptors and impeded neurotransmission. The typical symptoms of acute poisoning are agitation, muscle weakness, muscle fasciculations, miosis, hypersalivation, sweating.

Where are acetylcholinesterase found?

Acetylcholinesterase is a type-B carboxylesterase enzyme located primarily in the synaptic cleft with a smaller concentration in the extrajunctional area. Acetylcholinesterase is secreted by the muscle and remains attached to it by collagen fastened to the basal lamina.