What do meglitinides do?
What do meglitinides do?
The meglitinides are insulin secretagogues, stimulating the release of insulin from pancreatic beta cells in a manner similar to that of the sulfonylureas.
Why are meglitinides not used?
This study has demonstrated that hypoglycemia, and not meglitinide use, is associated with increased mortality. We showed that meglitinide indirectly could induce long-term mortality rate of by increasing their risk of hypoglycemia. Many antihyperglycemic agents and risk factors will increase the risk of hypoglycemia.
How does the meglitinides differ from the sulfonylureas?
Meglitinides (eg, repaglinide, nateglinide) are much shorter-acting insulin secretagogues than the sulfonylureas are, with preprandial dosing potentially achieving more physiologic insulin release and less risk for hypoglycemia.
How do sulfonylureas and meglitinides increase plasma insulin?
Sulfonylureas and meglitinides directly stimulate release of insulin from pancreatic beta cells and thereby lower blood glucose concentrations. Because they work by stimulating insulin secretion, they are useful only in patients with some beta cell function.
When are meglitinides used?
Meglitinides are oral medications used to treat type 2 diabetes. They work by triggering production of insulin. Medications in this class include Prandin (repaglinide) and Starlix (nateglinide).
Can sulfonylureas be used with meglitinides?
Although meglitinides can be used alone or together with other agents (e.g., metformin; Bailey, 2013), they should not be used with sulfonylureas because of their similar action (Kalra & Gupta, 2015; NIDDKD, 2015).
Under what condition is meglitinides contraindicated?
The use of meglitinides is contraindicated in patients with type I diabetes or for the treatment of diabetic ketoacidosis, with or without coma.
What is the action of metformin?
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
How do sulfonylureas and meglitinides help to lower blood glucose levels?
Sulfonylureas and meglitinides directly stimulate release of insulin from pancreatic beta cells and thereby lower blood glucose concentrations. Because they work by stimulating insulin secretion, they are useful only in patients with some beta cell function. Adverse effects may include weight gain and hypoglycemia.
What are the 2 meglitinides?
