What does CaMKII stand for?

Acronym. Definition. CaMKII. Ca(2+)/Calmodulin-Dependent Protein Kinase II (Calcium and Calmodulin dependent kinase)

What is CaMKII promoter?

The CaMKII’s promoter is a neuron-specific promoter. Its expression restricted to excitatory neurons in the neocortex and hippocampus, also pyramidal neurons. CaMKII promoter were used for transgene expression to obtain preferential gene expression in CNS for the excitatory neuron populations.

What neurons express CaMKII?

glutamatergic neurons
CaMKIIα-IR is known to be observed in a cell type specific manner, i.e. glutamatergic neurons in the neocortex, hippocampus and piriform cortex (Jones et al., 1994;McDonald et al., 2002;Benson et al., 1991;Zou et al., 2002).

Where is CaMKII found?

CaMKII is found in most tissues, but it is present in especially high concentrations in neurons, in which it may be up to 2% of total protein in some brain regions (Erondu and Kennedy, 1985). In mammals, the kinase is encoded by four genes, α, β, γ, and δ, with the α and β isozymes predominant in the brain.

Where is CaMKII located?

CAMKII Structure and Mechanism of Activation The enzyme is expressed mainly in the brain, but also in the rest of the tissues. In some regions of the brain, such as the hippocampus, the protein levels reach up to 2% of total proteins (Erondu and Kennedy, 1985; Hudmon and Schulman, 2002).

What is hSyn promoter?

hSyn confers highly neuron-specific long-term transgene expression in the adult rat brain. The AAV collection was developed by Sirion Biotech AG and is made available for research purposes only.

What is Synapsin promoter?

SYN1 promoter (Neurons) in pDRIVE expression plasmid Synapsin I is a neuron-specific phosphoprotein that coats the cytoplasmic surface of small synaptic vesicles. The proximal region of the synapsin I promoter (-422 to -22) is sufficient to direct neuron-specific gene expression.