What does CK7 positive and CK20 positive mean?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What does it mean when a tumor is positive for CK7?

For the CK7 negative group, no tumor cells yielded positive IHC staining results for CK7. For the CK7 positive group, diffuse or focal CK7 positive tumor cells were present in tumor tissue. The diffuse distribution of CK7 positive tumor cells was often present in poorly differentiated CRCs.

What is Pan cytokeratin stain?

The pan cytokeratin antibody may cross-react with GFAP, leading to aberrant positive staining of glial tumors such as ependymoma, glioblastoma, or schwannoma (Ordonez, 2013). .

What is CK7 in liver biopsy?

In addition to being expressed in bile ducts, bile ductules, and hepatic progenitor cells, CK7 is also expressed by hepatocytes in cholestatic conditions, such as biliary obstruction, primary biliary cirrhosis, primary sclerosing cholangitis, and chronic allograft rejection.

What does CK7 test for?

CK7 distinguishes between lung and breast epithelium that stain positive, and colon and prostate epithelial cells that are negative. It also reacts with many benign and malignant epithelial lesions, e.g. adenocarcinomas of the ovary, breast and lung.

What is CK7 marker?

Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. 305,306. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7. 307-309.

What is cytokeratin 7 and CK20?

Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) are low molecular weight cytokeratins. The expressions of CK7 and CK20 have been studied in various primary and metastatic carcinomas.

What does CK7 and CK20 stand for?

Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) are low molecular weight cytokeratins. The expressions of CK7 and CK20 have been studied in various primary and metastatic carcinomas. Their expression patterns may help to distinguish the site of origin of metastatic carcinomas.

Are CK7 and CK20 expression patterns different in colorectal carcinoma?

The CK7 and CK20 expression patterns were different in colorectal carcinomas according to histological grade, location of the tumor, and lymph node metastasis.

What is Ck 20 positivity in Merkel cell tumor?

In Merkel cell tumor, CK 20 positivity was dot-like cytoplasmic, whereas in other neoplasms, CK 20 positivity was diffuse cytoplasmic. Unlike CK 7, CK 20 expression was restricted to a few organ systems.