What does raltegravir interact with?
What does raltegravir interact with?
Aluminium and magnesium containing antacids reduce raltegravir plasma levels. Co-administration of raltegravir (400 mg twice daily and 1,200 mg once daily) with aluminium and/or magnesium containing antacids is not recommended.
What is raltegravir potassium used for?
Raltegravir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who weigh at least 4.5 lbs (2 kg). Raltegravir is in a class of medications called HIV integrase inhibitors. It works by decreasing the amount of HIV in the blood.
What is the half life of raltegravir?
The half-life of raltegravir is approximately 9 hours.
What is the mechanism of action of raltegravir?
MECHANISM OF ACTION Raltegravir is an antiretroviral drug used in the treatment of HIV-1 infection. The drug inhibits the activity of HIV-1 integrase, which impedes the insertion of HIV-1 DNA into the host cell genome.
Is there another name for raltegravir?
Raltegravir (brand names: Isentress and Isentress HD) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children.
Does raltegravir have side effects?
Raltegravir can cause serious, life-threatening side effects. These include severe skin rash and allergic reactions and liver problems. Contact your health care provider right away if you develop a rash while taking raltegravir.
What is the half life of Truvada?
Tenofovir is eliminated by a combination of glomerular filtration and active tubular secretion. Following a single oral dose of VIREAD, the terminal elimination half-life of tenofovir is approximately 17 hours.
What process does raltegravir inhibit?
Raltegravir inhibits integration at an IC50 of ~10 nM and the results are consistent with inhibition of the third step of the integration process (i.e. strand transfer). This prevents the incorporation of linear HIV-1 cDNA into the host cell’s genome and disrupts the viral life cycle of HIV.