What does streptolysin O do?

GAS leukotoxin streptolysin O (SLO) is able to form pores in host cell membranes, including neutrophils, macrophages and epithelial cells, which will lead to host cell apoptosis.

What is streptolysin O Pili?

Streptolysin O (SLO; slo), is a bacterial toxin that has four protein domains which is known to make the plasma membranes in animal cells permeable.

How does streptokinase work as a virulence factor?

Streptokinase is a virulence factor of streptococci and acts as a plasminogen activator to generate the serine protease plasmin which promotes bacterial metastasis.

What is the difference between streptolysin O and Streptolysin s?

Streptolysin O is oxygen-labile whereas streptolysin S is oxygen-stable. This means that streptolysin S is stable in the presence of atmospheric oxygen. In blood agar, the streptolysin S forms a zone of β hemolysis around the colonies of streptococci grown under routine aerobic conditions.

What causes elevated Antistreptolysin?

If you have elevated levels of ASO antibodies, it means that you have probably had a recent strep infection. If your levels are taken again later and are higher, it also means you’ve probably had a recent strep infection.

What is the action of streptokinase?

Streptokinase is a thrombolytic agent that is highly effective in its ability to lyse fibrin clots and restore blood flow to ischemic tissue.

How is streptokinase a virulence of streptococcus pyogenes?

Streptokinase is an important streptococcal virulence factor which has a critical role in the pathogenesis of invasive streptococcal diseases. The ability of streptokinase to activate host plasminogen to the broad spectrum protease plasmin facilitates the acquisition of plasmin activity onto the bacterial cell surface.

How is antistreptolysin O produced in the body?

The ASO titer test measures antibodies produced by your body in response to a toxin known as streptolysin O. Streptolysin O is a toxin produced by group A Streptococcus (GAS) bacteria. Your body makes the antistreptolysin O antibodies when you have a strep infection caused by GAS bacteria.

Why is streptolysin O oxygen labile?