What does the CDK4 gene do?
What does the CDK4 gene do?
Authors uncovered the role of cyclin-dependent kinase 4 (CDK4), a clinically validated kinase important for cell-cycle progression, in regulating cap-dependent translation via phosphorylation of the tumor suppressor 4E-BP1. High CDK4 expression is associated with tumor growth and metastasis in osteosarcoma.
Where is CDK6 located?
chromosome 7
The CDK6 gene is located on chromosome 7 in humans. The gene spans 231,706 base pairs and encodes a 326 amino acid protein with a kinase function. The gene is overexpressed in cancers like lymphoma, leukemia, medulloblastoma and melanoma associated with chromosomal rearrangements.
What is p27 in cell cycle?
p27 is a key regulator of cell proliferation. While it opposes cell cycle progression by binding to and inhibiting cyclin E-Cdk2, T157/T198 phosphorylation of p27 promotes its assembly of D-type cyclin-CDKs. In addition to its actions on the cell cycle, p27 regulates CDK-independent cytoplasmic functions.
What is Cdk2 and CDK4?
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol.
What is CDK4 gene mutation?
Mutations in CDK4 cause Melanoma Cancer Syndrome. People with an inherited mutation in CDK4 have increased risk for certain cancers. See the Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with an CDK4 mutation.
What do CDKs phosphorylate?
CDKs are a family of multifunctional enzymes that can modify various protein substrates involved in cell cycle progression. Specifically, CDKs phosphorylate their substrates by transferring phosphate groups from ATP to specific stretches of amino acids in the substrates.
What are CDK4 and CDK6?
Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular transition into S phase and are important for the initiation, growth and survival of many cancer types.
What is the function of cyclin A?
In addition to initiating DNA synthesis, Cyclin A ensures that DNA is replicated once per cell cycle by preventing the assembly of additional replication complexes. This is thought to occur through the phosphorylation of particular DNA replication machinery components, such as CDC6, by the cyclin A/CDK2 complex.
How does p27 inhibit CDK?
p27 can inhibit the catalytic activity of cyclin D-, E-, A-, and B-CDK complexes (2) by interacting with both cyclin and CDK subunits via its N-terminal domain, which is conserved among Kip family members (p21, p27, and p57; refs.
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