What drugs inhibit CYP2C19?

CYP2C19 strong inhibitors

  • Amitriptyline (Elavil®) [9]
  • Clomipramine (Anafranil®) [9]
  • Fluconazole (Diflucan®) [1]
  • Fluvoxamine (Luvox®) [1]
  • Imipramine (Tofranil®) [9]
  • Ticlopidine (Ticlid®) [1]

What are cyp2c8 inhibitors?

A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. An antiplatelet agent used to prevent blood clots in peripheral vascular disease, coronary artery disease, and cerebrovascular disease.

Do mice have CYP3A4?

In humans, four CYP3A P450s are expressed: CYP3A4, CYP3A5, CYP3A7 and CYP3A43. Interestingly, mice have eight CYP3A genes [12]. The most abundantly expressed CYP3A gene in humans is CYP3A4.

What drugs use CYP2C9?

Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for CYP2C9 include fluoxetine, losartan, phenytoin, tolbutamide, torsemide, S-warfarin, and numerous NSAIDs.

What happens if CYP2C19 is inhibited?

CYP2C19 Inhibitors Drugs that inhibit CYP2C19 activity (Table 2) are likely to increase the plasma concentrations of the medications listed with an asterisk in Table 1, and in some cases adverse outcomes may occur.

Does omeprazole inhibit CYP2C19?

Omeprazole is primarily converted by CYP2C19 to inactive metabolites. Omeprazole inhibits CYP2C19 and therefore its own metabolism. This leads to non-linear pharmacokinetics. The AUC response to dose increases is greater than linear in normal metabolizer patients at doses exceeding 40 mg.

Is clopidogrel a CYP2C8 inhibitor?

Clopidogrel, a CYP2C8 inhibitor, causes a clinically relevant increase in the systemic exposure to the active metabolite of selexipag in healthy subjects.

Do dogs have CYP2E1?

The canine CYP2E1 amino acid sequence has a higher identity with human CYP2E1 (77%) than with rodent or rabbit CYP2E1 (75–76%). However, the human CYP2E1 amino acid sequence has greater identity to rabbit and rodent CYP2E1 (78–79%) than to canine CYP2E1 (77%).

Is warfarin a CYP2C9 inhibitor?

Although R-warfarin is not metabolized by CYP2C9, this enantiomer binds and inhibits the enzyme with a Ki of ∼8 μM (13, 14).