What is AD-mix alpha?

What is AD-mix alpha?

AD-mix-α is a reagent used for Sharpless Asymmetric Dihydroxylation reactions.

What is DHQD?

Hydroquinidine 1,4-phthalazinediyl diether, commonly abbreviated as (DHQD)2PHAL, is a widely used ligand for the Sharpless asymmetric dihydroxylation reaction.

What is asymmetric epoxidation?

The Asymmetric Epoxidation, or AE, involves the conversion of an allylic alcohol to an epoxy alcohol. Titanium (IV) isopropoxide is used as a catalyst and (+) or (-) diethyl or diisopropyl tartrate as a chiral ligand.

What is the structure for the ligand used in AD-mix?

The AD mixes: AD-mix-alpha contains the ligand (DHQ)2PHAL and AD-mix-beta contains the ligand (DHDQ)2PHAL. The current recommended contents in 1 kilgram of AD mix are as follows: 699.6g K3Fe(CN)6, 293.9g K2CO3, 5.52g (DHQ)2- or (DHDQ)2-PHAL, and 1.04g K2OsO2(OH)4.

What compound is ad?

The two letters AD, stand for asymmetric dihydroxylation. The mix is available in two variations, “AD-mix α” and “AD-mix β” following ingredient lists published by Barry Sharpless.

How does Sharpless epoxidation work?

The Sharpless epoxidation reaction is an enantioselective chemical reaction to prepare 2,3-epoxyalcohols from primary and secondary allylic alcohols. The oxidizing agent is tert-butyl hydroperoxide. The method relies on a catalyst formed from titanium tetra(isopropoxide) and diethyl tartrate.

What reagent is in Sharpless Dihydroxylation?

These four reagents are commercially available premixed (“AD-mix”). The mixture containing (DHQ)2-PHAL is called AD-mix-α, and the mixture containing (DHQD)2-PHAL is called AD-mix-β….

What is enantioselective epoxidation?

Which reagent is used for Sharpless asymmetric Dihydroxylation?

These four reagents are commercially available premixed (“AD-mix”). The mixture containing (DHQ)2-PHAL is called AD-mix-α, and the mixture containing (DHQD)2-PHAL is called AD-mix-β….