What is DLPA DL-phenylalanine used for?

Abstract. In the author’s clinical experience, concurrent treatment with DL-phenylalanine (DLPA) often appears to potentiate pain relief and also ease depression in patients receiving opiates for chronic non-malignant pain.

Can you take DLPA every day?

For anxious or agitated patients, DLPA can sometimes be experienced as overly stimulating, while more mood-stable patients find it to be both pain-relieving and energy-enhancing. Our recommended DLPA dose is: 1000-2000mg, three times a day.

Can you overdose on DL-phenylalanine?

Doses higher than 5,000 mg a day may be toxic and can cause nerve damage. High quantities of DL-phenylalanine may cause mild side effects such as nausea, heartburn, and headaches.

Is DL-phenylalanine the same as phenylalanine?

Phenylalanine is an amino acid, a “building block” of protein. There are three forms of phenylalanine: D-phenylalanine, L-phenylalanine, and the mix made in the laboratory called DL-phenylalanine. D-phenylalanine is not an essential amino acid. Its role in the body is not currently understood.

How does DLPA make you feel?

In one double-blind trial, depressed people given 150–200 mg of DLPA per day experienced results comparable to that produced by an antidepressant drug. Several studies suggest that a synthetic version of phenylalanine called D-phenylalaline, may reduce pain by decreasing the enzyme that breaks down endorphins.

What are the benefits of DL phenylalanine?

Major dietary sources of L-phenylalanine include meat, fish, eggs, cheese, and milk. Phenylalanine is used for depression, attention deficit-hyperactivity disorder (ADHD), Parkinson’s disease, chronic pain, osteoarthritis, rheumatoid arthritis, alcohol withdrawal symptoms, and a skin disease called vitiligo.

How long does it take DLPA to work?

Supplementation with D-phenylalanine (DPA), a synthetic variation of the amino acid , L-phenylalanine (LPA), has reduced chronic pain due to osteoarthritis in a preliminary trial. In that study, participants took 250 mg three to four times per day, with pain relief beginning in four to five weeks.

When should I take dl phenylalanine?

For best results, phenylalanine should be taken between meals, because the protein present in food can interfere with the uptake of phenylalanine into the brain, potentially reducing its effect.

Does phenylalanine make you happy?

Preliminary research reported that L-phenylalanine improved mood in most of the depressed people studied. is a mixture of the essential amino acid L-phenylalanine and its synthetic mirror image, D-phenylalanine. DLPA (or the D- or L- form alone) reduced depression in 31 of 40 people in a preliminary trial.

Does D phenylalanine increase dopamine?

Benefits of phenylalanine Phenylalanine can also be used to produce dopamine, a molecule that plays a key role in mental health and depression (2, 10 ).