What is factor VII?

Factor VII, also called proconvertin, is one such clotting factor produced by the liver. It requires vitamin K for its production. Along with other clotting factors and blood cells, it promotes blood clotting at the site of an injury. It forms normal blood clots and closes the wound to prevent blood loss.

What is factor VII activated by?

Factor VII is feedback activated by many of the proteases produced during the blood coagulation response, but the extent of the thrombin production reaction is largely dependent on the preexistent concentration of factor VIIa in plasma and the concentration of tissue factor presented by the vascular lesion.

Where is factor VII found?

The gene for factor VII is located on chromosome 13 (13q34).

Is factor 7 hereditary?

Inheritance. Congenital factor VII deficiency is inherited in an autosomal recessive pattern , which means both copies of the F7 gene in each cell have mutations.

Is factor VIIa hemophilia?

Factor VII (7) deficiency is an inherited bleeding disorder caused when a person’s body does not produce enough of a protein in the blood (factor VII or FVII) that helps blood clot or the factor VII doesn’t work properly. The disorder is rare, affecting one in 500,000 people.

Does factor VII increase in pregnancy?

Literature indicates that whilst Factor VII levels rise during pregnancy in normal women, no increase is seen in homozygous cases, whereas there is a moderate rise in heterozygous individuals.

Which coagulation pathway is factor VII part of?

Factor VII is called stable factor. The common pathway consists of factors I, II, V, VIII, X.

Is factor 7 serious?

Factor VII (seven) deficiency is a disorder caused by a lack of a protein called factor VII in the blood. It leads to problems with blood clotting (coagulation). Blood clotting normally occurs when there is damage to a blood vessel.

Is Factor 7 a hemophilia?

Factor VII (FVII), or proconvertin, deficiency was first recognized in 1951. Considered the most common of rare bleeding disorders its incidence is estimated at 1 per 300,000-500,000.