What is Grafton allograft?

Grafton™ DBF is a demineralized bone allograft consisting of demineralized cortical fibers. The graft does not have any carriers and must be hydrated with blood/BMA/saline prior to its use in spine, orthopedic or reconstructive bone grafting procedures.

What is in demineralized bone matrix?

Demineralized bone matrix (DBM) is an osteoconductive scaffold that is manufactured by acid extraction of allograft bone. While it provides no structural support, it contains noncollagenous proteins, osteoinductive growth factors, and type I collagen.

What is Orthoblend?

Available in two distinct formulations, Grafton™ Orthoblend combines demineralized bone fibers with cancellous chips or crushed cancellous chips.

What is Grafton DBF?

Grafton™ DBF Inject is a precisely controlled bone graft delivery system that enables pre- and post-packing of graft material in the interbody space through integrated cannulas. It can be used with certain Medtronic interbody devices, when hydrated with bone marrow aspirate (BMA) for spinal and orthopedic procedures.

What is DBX Putty?

DBX Putty is indicated for treatment of surgically created osseous defects or osseous defects created from traumatic injury. DBX Putty provides a moldable consistency, can be mixed with blood or bone marrow, is composed of granulated cortical bone in sodium hyaluronate, and has 31% bone content (by weight).

What is BMP graft?

What are BMP and INFUSE Bone Graft? BMP is Bone Morphogenetic Protein. The active ingredient in INFUSE Bone Graft — rhBMP-2 — is a manufactured version of a protein already present in the body that promotes new bone growth.

What would be the result of demineralization of the bone matrix?

Demineralized allograft bone with osteoinductive activity. Demineralized bone matrices are prepared by acid extraction of allograft bone, resulting in loss of most of the mineralized component but retention of collagen and noncollagenous proteins, including growth factors.

Is demineralized bone matrix An allograft?

Demineralized bone matrix (DBM) is an allograft product with no quantity limitation. It is an osteoconductive material with osteoinductive capabilities, which vary among different products, depending on donor characteristics and differences in processing of the bone.

What is bioventus OsteoAMP?

OsteoAMP is a tissue based bone biologic product that is used by spine surgeons to promote natural bone growth and healing. OsteoAMP is a bone allograft made using a proprietary process designed to retain the bone’s natural growth factor complement.

What is DBM Putty?

DBM Putty is processed human bone that has been demineralized and combined with sodium hyaluronate, which is a naturally derived material not of animal origin that is both biocompatible and biodegradable.

Does dbx contain BMPs?

BMPs present and active in DBX It consists of colla- gen and bone growth factors such as bone morphogenic proteins1,2,3 (BMPs). The bone growth factors present and active inside of DBX, are responsible for its osteoinductive properties. They actively stimulate bone formation and regeneration1,2,3.

Is bone morphogenetic protein Safe?

Types of BMPs Although 20 different BMPs have been discovered, only BMP-2 is currently FDA approved and available in recombinant form for use in human spine surgery. BMP-7, or OP-1, was previously given a Humanitarian Device Exemption and ultimately was not approved by the FDA.

What is BMP for bone growth?

Bone Morphogenetic Protein or BMP is a product used in spinal fusion procedures. BMP is a protein that stimulates the growth of new bone and is used in many spinal fusion procedures. It is formally called recombinant human bone morphogenetic protein-2 or rhBMP-2.

What does bone demineralization mean?

Demineralized bone is bone that has had the calcium removed and is used to make bone tissue more conducive to spinal fusion. Bone morphogenic proteins from demineralized bone are added to a polymer or glycerol substrate to form a product that enhances bone growth.

What is a demineralized bone graft?

Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic “collagen” matrix. It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins.

How does demineralized bone matrix work?

Demineralized Bone Matrix (DBM) is a type of bone graft alternative that is processed from human allograft bone. DBM is processed by removing the mineral component of bone with acid, leaving behind the extracellular matrix composed of collagen and non-collagenous proteins, including the endogenous growth factors.

Is OsteoAMP FDA approved?

OsteoAmp® has not received FDA approval for any indication. information regarding treatments for tissue repair and tissue substitutes.

Who makes OsteoAMP?

Bioventus
DURHAM, NC – March 27, 2019 – Bioventus, a global leader in orthobiologic solutions, is launching OSTEOAMP SELECT Fibers, an innovative addition to its allograft line of OSTEOAMP bone graft substitutes for spine, foot & ankle, orthopaedic, and trauma surgeons.

Why is Osteoconductivity important in a bone graft?

Osteoconduction is the ability of bone-forming cells in the grafting area to move across a scaffold and slowly replace it with new bone over time. Osteoconductive materials serve as a scaffold onto which bone cells (osteoblasts and osteoclasts) can attach, migrate, grow and/or divide.

What is DBX allograft?

DBX® Demineralized Bone Matrix (DBM) is an allograft bone void filler processed by the Musculoskeletal Transplant Foundation (MTF).