What is Hyperhemolytic crisis?

Introduction: Hyperhemolytic crisis is a rare and dangerous complication of sickle cell disease where the hemoglobin level drops rapidly. This can quickly lead to organ failure and death. In the literature, most cases of hyperhemolysis in sickle cell patients followed a red cell transfusion.

What are the common early signs of sickle cell anemia?

What are the symptoms of sickle cell anemia?

  • excessive fatigue or irritability, from anemia.
  • fussiness, in babies.
  • bedwetting, from associated kidney problems.
  • jaundice, which is yellowing of the eyes and skin.
  • swelling and pain in hands and feet.
  • frequent infections.
  • pain in the chest, back, arms, or legs.

Which condition is most likely to create a vaso-occlusive crisis in patients?

Triggers of vaso-occlusive crisis Often, no precipitating cause can be identified. However, because deoxygenated hemoglobin S (HbS) becomes semisolid, the most likely physiologic trigger of vaso-occlusive crises is hypoxemia.

What is megaloblastic crisis?

Megaloblastic anemia is a condition in which the bone marrow produces unusually large, structurally abnormal, immature red blood cells (megaloblasts).

What is transient aplastic crisis?

Transient aplastic crisis (TAC) is a temporary cessation of red cell production by the bone marrow leading to severe anemia, most commonly seen in patients predisposed to increased RBC destruction.

What causes folate deficiency anemia?

Key points about folate-deficiency anemia Most folate-deficiency anemia is caused by a lack of folic acid in the diet. Leafy vegetables, citrus fruits, beans, and whole grains are natural sources of folic acid. Folate-deficiency anemia in pregnancy may cause a neural tube defect.

What are the effects of folate-deficiency anemia during pregnancy?

Folate-deficiency anemia during pregnancy may cause a neural tube defect. This is when the brain or spinal cord doesn’t develop normally. It can cause death before or soon after birth. Or it may cause paralysis of the legs. Folate-deficiency anemia is the lack of folic acid in the blood.

How is folate intake calculated for folic acid deficiency?

Because of variable absorption rates, an approximation of total folate intake in a day can be calculated as follows: Grams of DFEs provided = grams of food folate + 1.7 × (grams of folic acid supplementation) Khan KM, Jialal I. Folic Acid Deficiency. 2020 Jan. [Medline].

Can folic acid deficiency cause neural tube defects?

Folate-deficiency anemia in pregnancy may cause a neural tube defect. This is when the brain or spinal cord doesn’t develop normally. Treatment includes a well-balanced diet of foods with folic acid, folic acid supplements, medicines, and treating underlying diseases.