What is inosine in molecular biology?

Inosine is a purine nucleoside formed by hypoxanthine (IUPAC name: 1, 7 dihydropurin-6-one; molecular formula: C5H4N4O) linked by its N9 nitrogen to the C1 carbon of ribose (Figure 1A). Figure 1. Molecular inosine. (A) The N9 nitrogen of hypoxanthine is linked to the C1 carbon of ribose to form inosine.

What is the property of inosine?

Animal studies have suggested that inosine has neuroprotective properties. It has been proposed for spinal cord injury and for administration after stroke, because observation suggests that inosine induces axonal rewiring.

Is inosine an organic compound?

Inosine belongs to the class of organic compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Inosine is an extremely weak basic (essentially neutral) compound (based on its pKa).

What is the structural formula of adenosine?

C10H13N5O4Adenosine / Formula

Is inosine in the codon or anticodon?

More is known about inosine at position 34 because of its location in the anticodon loop. Inosine at this position allows recognition of multiple codons through wobble pairing, whereas adenosine at this position can only pair with uridine [38].

Is inosine a nucleotide?

Inosine triphosphate (ITP) is one of the most common non-canonical nucleotides. Cells hydrolyze ITP to its monophosphate to avoid incorporation in DNA.

What is inosine used for?

People use inosine for Parkinson disease, multiple sclerosis (MS), athletic performance, and many other conditions, but there is no good scientific evidence to support these uses.

What is inosine codon?

Inosine is a non-standard nucleotide present in naturally occurring mRNAs. a The I–C base pair forms two hydrogen bonds within the W–C geometry. b The mRNAs of 5-HT2CR and GluR-B are subject to A-to-I editing, thereby altering their genetic code. The editing sites are encircled.

What does inosine do in tRNA?

Abstract. The wobble inosine modification plays a central role in translation by enabling a single tRNA to decode multiple synonymous codons.