What is the DHE protocol?

Dihydroergotamine (DHE) infusion is a migraine treatment that works by therapeutically contracting some of the blood vessels that supply the tissues that cover and protect the brain. It also stops the release of natural substances in the brain that contribute to migraine pain.

Which medication is the most commonly used for migraine prophylaxis?

Beta-Blockers Propranolol is the most common and one of the most effective first-line medications used for migraine prophylaxis.

What is best treatment for migraine?

Many people who have migraines find that over-the-counter painkillers, such as paracetamol, aspirin and ibuprofen, can help to reduce their symptoms. They tend to be most effective if taken at the first signs of a migraine attack, as this gives them time to absorb into your bloodstream and ease your symptoms.

What is acute treatment for migraine?

Currently, for the acute treatment of migraine attacks, non-steroidal anti-inflammatory drugs (NSAIDs) and triptans (serotonin 5HT1B/1D receptor agonists) are recommended. Before intake of NSAID and triptans, metoclopramide or domperidone is useful. In very severe attacks, subcutaneous sumatriptan is first choice.

How is DHE given?

DHE can be injected into the muscle or under the skin, and patients can be taught to inject themselves. An injection is a useful option for those looking for effective, fast relief. The main possible side effects are nausea, injection site reactions (swelling or redness) and pain associated with the injection itself.

What migraine medicine does Serena Williams use?

In the migraine marketing wars, AbbVie just lobbed an ace: The Ubrelvy maker announced tennis phenom and migraine sufferer Serena Williams is its new spokesperson. Williams uses Ubrelvy to stop acute onset of the migraines she’s had all her life.

What is the latest treatment for migraines?

The Food and Drug Administration approved the most recent, atogepant (Qulipta), in September 2021. Lasmiditan (Reyvow) is a separate type of treatment that targets the serotonin receptors on brain nerve endings to halt migraine attacks as they occur.

Why is propranolol used for migraines?

Propranolol is a beta blocker that is sometimes prescribed for the prevention of migraines. It may work by preventing the dilation of blood vessels and stabilizing serotonin levels. If propranolol works for you, your migraine attacks will be shorter, less intense, and less frequent.