What is the difference between Optison and DEFINITY?

Preparation requirements for each of the agents differ: Definity requires activation with a mechanical agitator, Optison requires a resuspension of the bubbles by hand, and Lumason requires mixing and hand agitation.

What is optison used for?

Optison is used to obtain a clearer scan of the chambers of the heart, especially of the left ventricle, during echocardiography (a diagnostic test where an image of the heart is obtained using ultrasound).

Is DEFINITY contrast safe?

The federal Food and Drug Administration (FDA) is notifying healthcare professionals that the ultrasound contrast agents Definity , Definity RT and Lumason contain polyethylene glycol (PEG) and should not be administered to patients with known or suspected allergies to PEG.

What kind of drug is DEFINITY?

DEFINITY® is an injectable cardiovascular ultrasound enhancement agent comprised of lipid-coated echogenic microbubbles filled with octafluoropropane gas. Administration of DEFINITY® enhances clinicians’ view of the left ventricle of the heart during an echocardiogram to aid with diagnosis.

How do you do Optison contrast?

OPTISON is administered via an intravenous injection to allow the microspheres to enter the heart chamber and fill the left heart chamber. OPTISON is injected during the ultrasound examination in order to allow the doctor to assess the function of your heart. The recommended dose is 0.5 ml – 3.0 ml per patient.

Is DEFINITY a contrast agent?

Definity (perflutren lipid microsphere) Injectable Suspension is a contrast agent used to brighten and clarify images of the heart during echocardiograms.

How do you use Optison contrast?

The recommended dose of Optison is 0.5 mL injected into a peripheral vein. If the contrast enhancement is inadequate after the dose of 0.5 mL, additional doses in increments of 0.5 mL may be repeated for further contrast enhancement as needed. The maximum total dose should not exceed 5 mL in any 10 minute period.

Is optison a blood product?

Optison is classified as a medical imaging drug product by the FDA; it is not a blood product, even though the microsphere shell is made from a naturally occurring blood protein, albumin. In 2021, the FDA removed the hypersensitivity to blood and blood products contraindication for Optison.

What are the side effects of DEFINITY?

Common side effects of Definity include:

  • injection site reactions,
  • back and chest pain,
  • headache,
  • dizziness,
  • nausea,
  • flushing,
  • fatigue,
  • fever,

How long does DEFINITY stay in your body?

The activated DEFINITY may be used for up to 12 hours from the time of activation, but only after the microspheres are resuspended by hand agitation.

Can echo techs administer Definity?

This lab utilizes the Nuclear Medicine Techs to administer Definity.

What is Definity contrast?

Definity is an ultrasound contrast agent that is used to improve the quality of an echocardiogram (ultrasound of the heart). This medicine works by changing the way ultrasound waves travel within your heart. This helps the ultrasound portray a sharper image of your heart.