What is the mechanism of action of bilastine?

Bilastine is a new oral highly selective H1-receptor antagonist developed for the symptomatic treatment of allergic rhino-conjunctivitis and urticaria. It is an antiallergic agent whose main mechanism of action is the inhibition of immune system reactions mediated by the interaction of histamine on its H1- receptor.

What is bilastine 20 mg used for?

ILAXTEN contains the active substance bilastine which is an antihistamine. ILAXTEN is used to relieve the symptoms of hayfever (sneezing, itchy, runny, blocked-up nose and red and watery eyes) and other forms of allergic rhinitis. It may also be used to treat itchy skin rashes (hives or urticaria).

Why bilastine is non sedative?

Based on their ability to cross the blood–brain barrier, H1-antihistamines are classified into 2 groups: the first generation antihistamines that bind the H1-receptors on neurons in the central nervous system, causing sedation and impaired mental status, and the second-generation antihistamines (including bilastine) …

Is bilastine a strong antihistamine?

Abstract. Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine. In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.

Is bilastine an anticholinergic?

As far as studies in healthy volunteers, clinical assays and clinical experience can establish, bilastine’s safety profile is satisfactory, since it lacks anticholinergic effects, does not impair psychomotor performance or actual driving, and appears to be entirely free from cardiovascular effects.

Is bilastine a sedative?

Bilastine 20 mg once daily (therapeutic dose) is non-sedating, does not enhance the effects of alcohol or CNS sedatives, does not impair driving performance and has at least similar efficacy as other second-generation H1-antihistamines in the treatment of allergic rhinoconjunctivitis and urticaria.

Does bilastine cause sleep?

Bilastine is called a non-drowsy antihistamine; however, it can still cause drowsiness in a few people. Make sure your reactions are normal before you drive, or before using tools or machines.

Is bilastine and cetirizine same?

Bilastine is more effective than cetirizine at limiting the early allergic response, according to the results of a study in volunteers. Volunteers received a single oral dose of bilastine 20 mg, cetirizine 10 mg, or placebo, before provocation of a cutaneous wheal and flare response.

Which is better cetirizine or bilastine?

Is bilastine safe for kidneys?

Although exposure to bilastine was higher in renally impaired subjects, it remained well within the safety margins, thus allowing the conclusion that a 20-mg daily dose can be safely administered to subjects with different degrees of renal insufficiency without the need for dose adjustments.

Is bilastine stronger than cetirizine?

Which is best bilastine or levocetirizine?

In conclusion, bilastine demonstrated a better efficacy and less sedation for chronic spontaneous urticaria when compared to levocetirizine, however similar effect on quality of life.