What is Vogt-Koyanagi-Harada?

Vogt-Koyanagi-Harada disease is a rare disorder of unknown origin that affects many body systems, including as the eyes, ears, skin, and the covering of the brain and spinal cord (the meninges). The most noticeable symptom is a rapid loss of vision.

Does VKH go away?

Many patients with acute VKH go on to the chronic convalescent stage of VKH, about 3–4 months after the onset of the disease [9,10]. This usually lasts for some months or years [1,2].

Is VKH serious?

“VKH is usually severe panuveitis with an acute onset,” said Janet L. Davis, MD, an associate professor of ophthalmology at the Bascom Palmer Eye Institute in Miami. The disease “affects both eyes and can be seen in any age group.” Patients often present with exudative retinal detachments.

What is Vogt Koyanagi syndrome bilateral?

The Vogt-Koyanagi-Harada syndrome (VKH) is a bilateral, diffuse granulomatous uveitis associated with poliosis, vitiligo, alopecia, and central nervous system and auditory signs. These manifestations are variable and race dependent.

Is Vogt-Koyanagi-Harada autoimmune?

Vogt-Koyanagi-Harada disease (VKHD), initially described as an uveomeningoencephalitic syndrome, is a systemic granulomatous autoimmune disease that targets melanocyte-rich tissues, such as the eye, inner ear, meninges, skin and hair [1].

How do you test for VKH?

Diagnostic Procedures

  1. Fundus Fluorescein Angiography (FFA)
  2. Indocyanine Green Angiography (ICG)
  3. Fundus Autofluorescence (FAF)
  4. Optical Coherence Tomography (OCT)
  5. Ultrasonography.
  6. Electroretinography.
  7. Laboratory Tests.

How long does VKH treatment take?

evaluated 14 patients with VKH who were able to transition from 20 mg of oral prednisone to 4 mg at 6 months after initiation of adalimumab (34). Infliximab demonstrated efficacy in refractory cases of VKH with clinical remission being observed within a month or two of onset of treatment (37-39).

What causes Vkh syndrome?

The exact cause of VKH disease is unknown, but the symptoms are thought to be due to an abnormal response of the immune system to a viral infection. Genetic factors may be involved. Diagnosis of VKH disease is based on the symptoms, clinical exam, and imaging studies.

Is VKH an autoimmune disease?

Vogt-Koyanagi-Harada (VKH) disease is a multisystem autoimmune inflammatory disorder with ocular, auditory, skin and neurologic involvement. VKH disease occurs more commonly in patients with a genetic predisposition to the disease, including those from Asian, Middle Eastern, Hispanic, and Native American populations.

Is VKH a disability?

Vogt-Koyanagi-Harada disease (VKHD) is also a rare multisystemic, granulomatous inflammatory condition that targets melanocytic tissues, such as the eye, inner ear, meninges, skin, and hair. VKHD is usually characterized by bilateral panuveitis, which is a common cause of visual disability.

Is there a cure for VKH?

Vogt–Koyanagi–Harada is a Curable Autoimmune Disease: Early Diagnosis and Immediate Dual Steroidal and Non-Steroidal Immunosuppression are Crucial Prerequisites.

What is sunset glow fundus?

The “sunset glow” fundus is a depigmentary change in melanocytes in the choroid that appears 2–6 months after VKH disease onset. The fundus pigmentation is variable even among normal individuals, and in its subjective evaluation by ophthalmoscopy, the fundus picture fails to provide a quantitative assessment.

What is Coat’s Disease?

Coats disease is a telangiectatic neovascular disease of the retina of unknown etiology that frequently affects unilateral eyes of young males. George Coats in 1908 described the histopathological features of enucleated eyes with massive exudation.

What causes central serous Chorioretinopathy?

Central serous chorioretinopathy is a disease that causes fluid to build up under the retina, the back part of the inner eye that sends sight information to the brain. The fluid leaks from the choroid (the blood vessel layer under the retina). The cause of this condition is unknown but stress can be a risk factor.

How is coat disease diagnosed?

Coats’ disease is diagnosed by direct visualization of the retinal vessels, and special imaging modalities such as ultrasound, fluorescein angiography, optical coherence tomography (OCT) and OCT angiography (OCTA).

Can VKH be cured?

What is Harada disease?

Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele.

What is the treatment of CSR?

Most people with CSR don’t require treatment. If treatment is required then thermal laser or photodynamic therapy (PDT) may be used.

What is the treatment of central serous chorioretinopathy?

Several therapies have been used to treat chronic CSC, including thermal laser treatments, oral medications, and eye injections. A “cold laser,” called photodynamic therapy, is also effective and often used to focally treat the source of fluid leakage under the retina in chronic CSC.

Is there treatment for Coats disease?

There’s no cure for Coats disease, but early treatment can improve your chances of retaining your eyesight. Most people respond well to treatment. But about 25 percent of people experience continued progression that leads to removal of the eye.

Who discovered Coats disease?

This disease entity was first described by a Scottish ophthalmologist, George Coats, in 1908. It is a relatively rare disease, with a reported incidence of 0.09 per 100,000 of the population.

What is CSR disease?

Central Serous Chorioretinopathy or Central Serous Retinopathy (CSC or CSR) is a disorder that causes the accumulation of fluid under the macula in an otherwise healthy eye. This accumulation of fluid under the macula causes blurring of the central vision in the affected eye.

What drugs cause central serous retinopathy?

The causes of CSC are not fully understood. It is thought that any systemic exposure to a corticosteroid drug can bring about or worsen CSC. Corticosteroids are found in allergy nose sprays and anti-inflammatory skin creams available over the counter, and are often prescribed to treat a variety of medical conditions.