What produces il7?

IL-7 is produced by mesenchymal and epithelial cells in lymphoid organs. In the thymus, IL-7 mRNA is detected in thymic epithelial cells (TECs) by in situ hybridization, especially at the corticomedullary junction (12). Additionally, IL-7 is expressed in the mesenchymal stromal cell lines isolated from thymus (13).

What cells express IL 7R?

The IL7R is expressed on naïve T cells and is downregulated following TCR engagement (8, 9, 13-21). T cells then have the capacity to upregulate the IL7R for their continued maintenance (22-24). However, when T cells are continuously stimulated, they fail to re-express the IL7R (15).

Do NK cells express IL7R?

Natural killer (NK) cells are similar to ILC1s but are not considered part of the helper ILC subset and generally do not express the IL-7Rα (45). However, some tissue NK cells express a range of IL-7Rα levels, like in the thymus, colon, and small intestine lamina propria (siLP) (46, 47).

What is IL7R marker?

The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells.

What is the function of IL 10?

Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis.

Is interleukin a hormone?

IL-6 is a hormonally regulated cytokine. Its production is suppressed by glucocorticoids (4) and estrogens (5) and stimulated by catecholamines (6, 7). In turn, it has many endocrine effects.

Where is interleukin produced?

The majority of interleukins are synthesized by CD4 helper T-lymphocyte, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells.