Why temozolomide is used for glioblastoma?

The addition of temozolomide regimen improved the overall survival and progression-free survival in patients with GBM compared with radiotherapy alone. Temozolomide is a lipophilic molecule that crosses the blood-brain barrier and is stable at the acidic pH of the stomach and is therefore administered orally.

How effective is temozolomide on unmethylated glioblastoma?

During the past 15 years, studies have repeatedly demonstrated that it is the 45% to 55% of patients with glioblastoma with at least partial methylation of the O6-methylguanine-DNA methyltransferase promoter (MGMTp) who benefit from the addition of temozolomide to their treatment regimen.

How effective is temozolomide?

With temozolomide, median survival reached 15 to 16 months, with a 2-year survival rate of 27%. With the addition of tumor-treating fields, the median survival is over 20 months, and over 40% of patients are alive at 2 years.

How effective is chemotherapy for glioblastoma?

(64) reported on 48 patients with recurrent GBM treated with bevacizumab followed by bevacizumab plus irinotecan at progression of tumor. The median survival and progression-free survival were 31 weeks and 16 weeks, with a respective 6-month survival and progression-free survival of 57% and 29%.

Is temozolomide well tolerated?

Temozolomide (TMZ) is a well-tolerated, second-generation alkylating agent with excellent penetration into to the CNS and the cerebrospinal fluid (CSF).

How many cycles of temozolomide can you have?

You can have up to 12 cycles of treatment with temozolomide.

How long can you take temozolomide for?

You usually take temozolomide once a day for between 6 to 7 weeks.

How long can you take temozolomide?

What are the side effects of temozolomide?

Temozolomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • constipation.
  • loss of appetite.
  • sores in the mouth and throat.
  • headache.
  • pale skin.

When is the best time to take temozolomide?

Temozolomide comes as a capsule to take by mouth. It is usually taken once a day in the evening at bedtime. Take temozolomide capsules on an empty stomach with a glass of water. Take temozolomide at around the same time every day.

What are the long term side effects of temozolomide?

What are the side-effects of temozolomide?

  • Fatigue. People have reported feeling tired during treatment and for up to 12 months afterwards.
  • Nausea and vomiting.
  • Constipation.
  • Loss of appetite.
  • Amenorrhoea (an absence of periods)
  • Infection.
  • Low platelet count.
  • Loss of fertility.