What does TGFB2 do?

The TGFB2 gene provides instructions for producing a protein called transforming growth factor beta-2 (TGFβ-2). This protein is found throughout the body and is required for development before birth and throughout life. To carry out its functions, TGFβ-2 attaches (binds) to receptor proteins on the surface of cells.

What is the difference between tgfb1 and TGFB2?

TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems.

What causes high TGF-beta?

What does it mean if your TGF-b1 result is too high? – TGF B-1 is often chronically over-expressed in disease states, including cancer, fibrosis and inflammation. – TGF B-1 is moderately to extremely high in Chronic Inflammatory Response Syndrome due to water-damaged buildings (CIRS).

What causes high tgfb1?

– TGF B-1 is often chronically over-expressed in disease states, including cancer, fibrosis and inflammation. – TGF B-1 is moderately to extremely high in Chronic Inflammatory Response Syndrome due to water-damaged buildings (CIRS).

What is TGF in immunology?

Abstract. Transforming growth factor-beta (TGF-beta) is a potent regulatory cytokine with diverse effects on hemopoietic cells. The pivotal function of TGF-beta in the immune system is to maintain tolerance via the regulation of lymphocyte proliferation, differentiation, and survival.

What does high TGF B mean?

What does the TGFB1 gene do?

The TGFβ-1 protein triggers chemical signals that regulate various cell activities inside the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis).

What does high TGF beta mean?

What cells produce TGF?

TGF-β1 can be produced by multiple lineages of leukocytes and stromal cells and is secreted as a latent form in a complex with LAP and LTBP (Figure 1).