What is a syngeneic cell line?

Syngeneic Cell Line Derived Tumor Models Syngeneic models, also known as the mouse homograft tumors, have been regarded as a surrogate transplanted tumor platform (as opposite to human xenograft tumors) for in vivo pharmacological studies.

What is a syngeneic model?

What is a syngeneic mouse model? Syngeneic mouse models, also known as Allograft mouse tumor systems, consist of tumor tissues derived from the same genetic background as a given mouse strain. As the syngeneic mice retain intact immune systems, they are particularly relevant for studies of immunotherapies.

What is the 4T1 cell line?

4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine. In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.

What is bt474 cell line?

BT-474 is a cell line exhibiting epithelial morphology that was isolated from a solid, invasive ductal carcinoma of the breast obtained from a 60-year-old, White, female breast cancer patient. Use these cells in your cancer research.

What is a syngeneic donor?

Syngeneic. The donor is an identical twin of the patient. This is the simplest source of stem cells. Syngeneic transplants are the least complicated transplants because there is no risk of rejection, graft-versus-host disease (GVHD), or tumor in the marrow.

Are 4T1 cells human?

The tumor growth and metastatic spread of 4T1 cells in BALB/c mice very closely mimic human breast cancer. This tumor-derived cell line is an animal model for stage IV human breast cancer.

Is 4T1 triple negative?

4T1 is a triple-negative mouse breast cancer cell line. Pharmatest utilises a 4T1 cell line with stable expression of green fluorescent protein (GFP) enabling easy and efficient detection of whole-body tumour burden. Use of immunocompetent mice in 4T1 models allows efficacy testing of immonomodulatory compounds.

What are cell lines used for?

Cell lines have revolutionized scientific research and are being used in vaccine production, testing drug metabolism and cytotoxicity, antibody production, study of gene function, generation of artificial tissues (e.g., artificial skin) and synthesis of biological compounds e.g., therapeutic proteins.

What is syngeneic transfer?

(SIN-jeh-NAY-ik bone MAYR-oh TRANZ-plant) A procedure in which a patient receives healthy stem cells (blood-forming cells) to replace their own stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy.

What is the difference between syngeneic and allogeneic?

A syngeneic stem cell transplant is a type of allogeneic transplant, meaning it comes from a donor. You can only receive a syngeneic transplant if you have an identical twin or triplet who can donate stem cells.